The Nervous System: An Ideal Therapeutic Target for Anti-Schistosomal Drug Discovery
نویسندگان
چکیده
منابع مشابه
The Nervous System: An Ideal Therapeutic Target for Anti-Schistosomal Drug Discovery
Volume 1 • Issue 1 • 1000e103 Schistosomiasis is a parasitic disease that afflicts over 200 million people worldwide, causing visceral organ disturbance, and impairing growth and cognitive development in children [1]. The etiological agents of human schistosomiasis are the blood flukes of the genus Schistosoma, including S. mansoni, S. haematobium, and S. japonicum. S. mansoni is blamed for ove...
متن کاملCaenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and function...
متن کاملDrug Normalization for Cancer Therapeutic and Druggable Genome Target Discovery
Heterogeneous drug data representation among different druggable genome knowledge resources and datasets delays effective cancer therapeutic target discovery within the broad scientific community. The objective of the present paper is to describe the challenges and lessons learned from our efforts in developing and evaluating a standards-based drug normalization framework targeting cancer drugg...
متن کاملTherapeutic Potential of Plants as Anti-microbials for Drug Discovery
The uses of traditional medicinal plants for primary health care have steadily increased worldwide in recent years. Scientists are in search of new phytochemicals that could be developed as useful anti-microbials for treatment of infectious diseases. Currently, out of 80% of pharmaceuticals derived from plants, very few are now being used as anti-microbials. Plants are rich in a wide variety of...
متن کاملMycobacterial CYP121 as a target for anti-TB drug discovery
Despite the introduction of the first line treatment regimen forty years ago and the continuous trials since that time to introduce new regimens, tuberculosis (TB) is considered to be the cause of considerable mortality worldwide. Recent research highlighted the Mycobacterium tuberculosis (Mtb)CYP450s as potential drug targets. This article reviews mycobacterial CYP121 as a target for anti-TB d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tropical Medicine & Surgery
سال: 2013
ISSN: 2329-9088
DOI: 10.4172/2329-9088.1000e103